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Cat. No. | Product Name | ||
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L4100 | TGF-β/Smad靶点化合物库 | 184 compounds | |
184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3636 |
(E)-SIS3
SIS3,SIS3 盐酸盐,SIS3 HCl |
TGF-beta/Smad | Stem Cells |
(E)-SIS3 (SIS3) 是 Smad3 的选择性抑制剂,能够抑制 Smad3 磷酸化(IC50:3 μM)。它利用 TGF-β1 抑制成纤维细胞向肌成纤维细胞分化。 | |||
T11052L |
Disitertide acetate
P144 acetate,Disitertide acetate(272105-42-7 Free base) |
TGF-beta/Smad | Stem Cells |
Disitertide acetate (P144 acetate) 是转化生长因子 TGFβ1 的多肽抑制剂,特异性的阻断其与受体间的相互作用。Disitertide acetate 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。 | |||
T80272 |
Vicatertide
SB-01 |
||
Vicatertide为TGF beta-1抑制剂。 | |||
T79603 |
3,7-DMF
|
TGF-beta/Smad | Stem Cells |
3,7-DMF作为一种口服活性抑制剂,有效抑制了TGF-β1诱导的HSC活化,并通过诱导抗氧化基因及淬灭ROS为研究肝纤维化提供了潜在应用。 | |||
T75716 |
Disitertide TFA
|
||
Disitertide (P144) TFA 是转化生长因子TGFβ1的多肽抑制剂,特异性的阻断其与受体间的相互作用。Disitertide TFA 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。 | |||
T75717 |
Disitertide diammonium
|
||
Disitertide (P144) diammonium 是转化生长因子TGFβ1的多肽抑制剂,特异性的阻断其与受体间的相互作用。Disitertide diammonium 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13741 |
Isoviolanthin
异佛莱心苷,异佛来心苷 |
Others | Others |
Isoviolanthin 是一种黄酮类苷类化合物,提取自铁皮石斛叶中。它能减少 TGF-β1 处理的 HCC 细胞的迁移和入侵能力,对正常细胞没有毒性影响,对转移性肝癌晚期具有潜在的研究价值。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02638 |
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant
transforming growth factor, beta ... |
Human,Rhesus,Cynomolgus,Canine | CHO Cells |
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.8 kDa and the accession number is A0A499FJK2. | |||
TMPY-00608 |
TGF beta 1 Protein, Rat/Mouse, Recombinant
transforming growth factor, beta ... |
Mouse,Rat | HEK293 Cells |
TGF beta 1 Protein, Rat/Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.8 kDa. | |||
TMPY-04211 |
Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His)
transforming growth factor, β... |
Cynomolgus | HEK293 Cells |
Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa. | |||
TMPY-03945 |
Latent TGF beta 1 Protein, Rat, Recombinant (His)
TGF β1,transforming growth fa... |
Rat | HEK293 Cells |
Latent TGF beta 1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P17246. | |||
TMPY-00500 |
Latent TGF beta 1 Protein, Mouse, Recombinant (His)
transforming growth factor, beta ... |
Mouse | HEK293 Cells |
Latent TGF beta 1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P04202. | |||
TMPY-01133 |
Latent TGF beta 1 Protein, Human, Recombinant (His)
CED,DPD1,transforming growth factor |
Human | HEK293 Cells |
Latent TGF beta 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the accession number is A0A499FJK2. | |||
TMPJ-00249 |
TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
TGF-Beta-1,TGFB1,Transforming Growth F... |
Human | HEK293 Cells |
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family... | |||
TMPY-00229 |
Latent TGF beta 1 Protein, Canine, Recombinant (His)
transforming growth factor, β... |
Canine | HEK293 Cells |
Latent TGF beta 1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa. | |||
TMPY-05313 |
Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated
transforming growth factor, beta ... |
Mouse | HEK293 Cells |
Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P04202. | |||
TMPY-05521 |
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated
TGFB,TGF β1,转化生长因子,TGF-beta 1,transforming... |
Human | HEK293 Cells |
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the accession number is A0A499FJK2. | |||
TMPJ-00772 |
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Transforming growth factor β-1,La... |
Mouse | HEK293 Cells |
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-8xHis-Avi tag. The predicted molecular weight is 13 and 35-45 KDa and the accession number is P04202. | |||
TMPJ-00622 |
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
转化生长因子,Transforming growth factor... |
Cynomolgus | HEK293 Cells |
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 11 and 35-45 KDa and the accession number is F7HCV5. | |||
TMPJ-00250 |
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
transforming growth factor β1... |
Human | HEK293 Cells |
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activation of these complexes is a critical step in regulation of TGFβ function in vivo. The TGFβ1 LAP is a ligand for the integrin αvβ6 and that αvβ6-expressing cells induce spatially restricted activition of TGFβ1. And LAP identifies a novel CD4+/CD25+ regulatory T cell subset with ... | |||
TMPJ-00771 |
TGF beta 1 Protein, Mouse/Rat, Recombinant
TGFB,TGFbeta,CEDLAP,TGF-beta-1,TGF-beta 1 protein,latency-as... |
Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II)... |